diff --git a/i2c_smbus/i2c_smbus_i801.cpp b/i2c_smbus/i2c_smbus_i801.cpp
index dade359c..c321f459 100644
--- a/i2c_smbus/i2c_smbus_i801.cpp
+++ b/i2c_smbus/i2c_smbus_i801.cpp
@@ -9,8 +9,9 @@
 \*-----------------------------------------*/
 
 #include "i2c_smbus_i801.h"
+#include "ResourceManager.h"
+
 #ifdef _WIN32
-#include <Windows.h>
 #include "OlsApi.h"
 #elif _MACOSX_X86_X64
 #include "macUSPCIOAccess.h"
@@ -20,6 +21,33 @@
 
 using namespace std::chrono_literals;
 
+i2c_smbus_i801::i2c_smbus_i801()
+{
+#ifdef _WIN32
+    json drivers_settings = ResourceManager::get()->GetSettingsManager()->GetSettings("Drivers");
+
+    bool shared_smbus_access = true;
+    if(drivers_settings.contains("shared_smbus_access"))
+    {
+        shared_smbus_access = drivers_settings["shared_smbus_access"].get<bool>();
+    }
+    if(shared_smbus_access)
+    {
+        global_smbus_access_handle = CreateMutexA(NULL, FALSE, GLOBAL_SMBUS_MUTEX_NAME);
+    }
+#endif
+}
+
+i2c_smbus_i801::~i2c_smbus_i801()
+{
+#ifdef _WIN32
+    if(global_smbus_access_handle != NULL)
+    {
+        CloseHandle(global_smbus_access_handle);
+    }
+#endif
+}
+
 /* Return negative errno on error. */
 s32 i2c_smbus_i801::i801_access(u16 addr, char read_write, u8 command, int size, i2c_smbus_data *data)
 {
@@ -486,7 +514,23 @@ int i2c_smbus_i801::i801_wait_intr()
 
 s32 i2c_smbus_i801::i2c_smbus_xfer(u8 addr, char read_write, u8 command, int size, i2c_smbus_data* data)
 {
-    return i801_access(addr, read_write, command, size, data);
+#ifdef _WIN32
+    if(global_smbus_access_handle != NULL)
+    {
+        WaitForSingleObject(global_smbus_access_handle, INFINITE);
+    }
+#endif
+
+    s32 result = i801_access(addr, read_write, command, size, data);
+
+#ifdef _WIN32
+    if(global_smbus_access_handle != NULL)
+    {
+        ReleaseMutex(global_smbus_access_handle);
+    }
+#endif
+
+    return result;
 }
 
 s32 i2c_smbus_i801::i2c_xfer(u8 addr, char read_write, int* size, u8* data)
diff --git a/i2c_smbus/i2c_smbus_i801.h b/i2c_smbus/i2c_smbus_i801.h
index d6cfe9c1..80d7cb2e 100644
--- a/i2c_smbus/i2c_smbus_i801.h
+++ b/i2c_smbus/i2c_smbus_i801.h
@@ -10,6 +10,10 @@
 
 #include "i2c_smbus.h"
 
+#ifdef _WIN32
+#include <Windows.h>
+#endif
+
 #pragma once
 
 /* BIT shifting macro */
@@ -81,10 +85,16 @@
 #define SMBHSTCFG               0x040
 #define SMBHSTCFG_HST_EN        BIT(0)
 
+#ifdef _WIN32
+#define GLOBAL_SMBUS_MUTEX_NAME "Global\\Access_SMBUS.HTP.Method"
+#endif
+
 class i2c_smbus_i801 : public i2c_smbus_interface
 {
 public:
     u16 i801_smba = 0xF000;
+    i2c_smbus_i801();
+    ~i2c_smbus_i801();
 
 private:
     s32 i801_access(u16 addr, char read_write, u8 command, int size, i2c_smbus_data *data);
@@ -97,4 +107,8 @@ private:
     int i801_wait_intr();
     s32 i2c_smbus_xfer(u8 addr, char read_write, u8 command, int size, i2c_smbus_data* data);
     s32 i2c_xfer(u8 addr, char read_write, int* size, u8* data);
-};
\ No newline at end of file
+
+#ifdef _WIN32
+    HANDLE global_smbus_access_handle = NULL;
+#endif
+};
diff --git a/i2c_smbus/i2c_smbus_nct6775.cpp b/i2c_smbus/i2c_smbus_nct6775.cpp
index 23c47916..03950231 100644
--- a/i2c_smbus/i2c_smbus_nct6775.cpp
+++ b/i2c_smbus/i2c_smbus_nct6775.cpp
@@ -7,12 +7,35 @@
 \*-----------------------------------------*/
 
 #include "i2c_smbus_nct6775.h"
-#include <Windows.h>
 #include "OlsApi.h"
 #include "LogManager.h"
+#include "ResourceManager.h"
 
 using namespace std::chrono_literals;
 
+i2c_smbus_nct6775::i2c_smbus_nct6775()
+{
+    json drivers_settings = ResourceManager::get()->GetSettingsManager()->GetSettings("Drivers");
+
+    bool shared_smbus_access = true;
+    if(drivers_settings.contains("shared_smbus_access"))
+    {
+        shared_smbus_access = drivers_settings["shared_smbus_access"].get<bool>();
+    }
+    if(shared_smbus_access)
+    {
+        global_smbus_access_handle = CreateMutexA(NULL, FALSE, GLOBAL_SMBUS_MUTEX_NAME);
+    }
+}
+
+i2c_smbus_nct6775::~i2c_smbus_nct6775()
+{
+    if(global_smbus_access_handle != NULL)
+    {
+        CloseHandle(global_smbus_access_handle);
+    }
+}
+
 s32 i2c_smbus_nct6775::nct6775_access(u16 addr, char read_write, u8 command, int size, i2c_smbus_data *data)
 {
     int i, len, status, cnt;
@@ -186,7 +209,19 @@ s32 i2c_smbus_nct6775::nct6775_access(u16 addr, char read_write, u8 command, int
 
 s32 i2c_smbus_nct6775::i2c_smbus_xfer(u8 addr, char read_write, u8 command, int size, i2c_smbus_data* data)
 {
-    return nct6775_access(addr, read_write, command, size, data);
+    if(global_smbus_access_handle != NULL)
+    {
+        WaitForSingleObject(global_smbus_access_handle, INFINITE);
+    }
+
+    s32 result = nct6775_access(addr, read_write, command, size, data);
+
+    if(global_smbus_access_handle != NULL)
+    {
+        ReleaseMutex(global_smbus_access_handle);
+    }
+
+    return result;
 }
 
 s32 i2c_smbus_nct6775::i2c_xfer(u8 addr, char read_write, int* size, u8* data)
diff --git a/i2c_smbus/i2c_smbus_nct6775.h b/i2c_smbus/i2c_smbus_nct6775.h
index a9af8fb7..872d65f2 100644
--- a/i2c_smbus/i2c_smbus_nct6775.h
+++ b/i2c_smbus/i2c_smbus_nct6775.h
@@ -7,6 +7,7 @@
 \*-----------------------------------------*/
 
 #include "i2c_smbus.h"
+#include <Windows.h>
 
 #pragma once
 
@@ -44,15 +45,19 @@
 /* Other settings */
 #define NCT6775_MAX_RETRIES    400
 
+#define GLOBAL_SMBUS_MUTEX_NAME "Global\\Access_SMBUS.HTP.Method"
 
 class i2c_smbus_nct6775: public i2c_smbus_interface
 {
 public:
     u16 nct6775_smba = 0x0290;
+    i2c_smbus_nct6775();
+    ~i2c_smbus_nct6775();
 
 private:
     s32 nct6775_access(u16 addr, char read_write, u8 command, int size, i2c_smbus_data *data);
     s32 i2c_smbus_xfer(u8 addr, char read_write, u8 command, int size, i2c_smbus_data* data);
     s32 i2c_xfer(u8 addr, char read_write, int* size, u8* data);
 
+    HANDLE global_smbus_access_handle = NULL;
 };
diff --git a/i2c_smbus/i2c_smbus_piix4.cpp b/i2c_smbus/i2c_smbus_piix4.cpp
index fe2cf875..9818c301 100644
--- a/i2c_smbus/i2c_smbus_piix4.cpp
+++ b/i2c_smbus/i2c_smbus_piix4.cpp
@@ -16,13 +16,12 @@
 i2c_smbus_piix4::i2c_smbus_piix4()
 {
     json drivers_settings = ResourceManager::get()->GetSettingsManager()->GetSettings("Drivers");
-    bool amd_smbus_reduce_cpu = false;
 
+    bool amd_smbus_reduce_cpu = false;
     if(drivers_settings.contains("amd_smbus_reduce_cpu"))
     {
         amd_smbus_reduce_cpu = drivers_settings["amd_smbus_reduce_cpu"].get<bool>();
     }
-
     if(amd_smbus_reduce_cpu)
     {
         delay_timer = CreateWaitableTimerExW(NULL, NULL, CREATE_WAITABLE_TIMER_MANUAL_RESET | CREATE_WAITABLE_TIMER_HIGH_RESOLUTION, TIMER_ALL_ACCESS);
@@ -31,6 +30,16 @@ i2c_smbus_piix4::i2c_smbus_piix4()
             delay_timer = CreateWaitableTimer(NULL, TRUE, NULL); // create regular timer instead
         }
     }
+
+    bool shared_smbus_access = true;
+    if(drivers_settings.contains("shared_smbus_access"))
+    {
+        shared_smbus_access = drivers_settings["shared_smbus_access"].get<bool>();
+    }
+    if(shared_smbus_access)
+    {
+        global_smbus_access_handle = CreateMutexA(NULL, FALSE, GLOBAL_SMBUS_MUTEX_NAME);
+    }
 }
 
 i2c_smbus_piix4::~i2c_smbus_piix4()
@@ -39,6 +48,11 @@ i2c_smbus_piix4::~i2c_smbus_piix4()
     {
         CloseHandle(delay_timer);
     }
+
+    if(global_smbus_access_handle != NULL)
+    {
+        CloseHandle(global_smbus_access_handle);
+    }
 }
 
 //Logic adapted from piix4_transaction() in i2c-piix4.c
@@ -221,7 +235,19 @@ s32 i2c_smbus_piix4::piix4_access(u16 addr, char read_write, u8 command, int siz
 
 s32 i2c_smbus_piix4::i2c_smbus_xfer(u8 addr, char read_write, u8 command, int size, i2c_smbus_data* data)
 {
-    return piix4_access(addr, read_write, command, size, data);
+    if(global_smbus_access_handle != NULL)
+    {
+        WaitForSingleObject(global_smbus_access_handle, INFINITE);
+    }
+
+    s32 result = piix4_access(addr, read_write, command, size, data);
+
+    if(global_smbus_access_handle != NULL)
+    {
+        ReleaseMutex(global_smbus_access_handle);
+    }
+
+    return result;
 }
 
 s32 i2c_smbus_piix4::i2c_xfer(u8 addr, char read_write, int* size, u8* data)
diff --git a/i2c_smbus/i2c_smbus_piix4.h b/i2c_smbus/i2c_smbus_piix4.h
index 091da1ef..71bb1be7 100644
--- a/i2c_smbus/i2c_smbus_piix4.h
+++ b/i2c_smbus/i2c_smbus_piix4.h
@@ -37,6 +37,8 @@
 #define PIIX4_WORD_DATA         0x0C
 #define PIIX4_BLOCK_DATA        0x14
 
+#define GLOBAL_SMBUS_MUTEX_NAME "Global\\Access_SMBUS.HTP.Method"
+
 class i2c_smbus_piix4 : public i2c_smbus_interface
 {
 public:
@@ -50,4 +52,5 @@ private:
     s32 i2c_smbus_xfer(u8 addr, char read_write, u8 command, int size, i2c_smbus_data* data);
     s32 i2c_xfer(u8 addr, char read_write, int* size, u8* data);
     HANDLE delay_timer;
+    HANDLE global_smbus_access_handle = NULL;
 };
diff --git a/qt/OpenRGBSettingsPage.cpp b/qt/OpenRGBSettingsPage.cpp
index 41bda7a7..bc332da0 100644
--- a/qt/OpenRGBSettingsPage.cpp
+++ b/qt/OpenRGBSettingsPage.cpp
@@ -92,9 +92,19 @@ OpenRGBSettingsPage::OpenRGBSettingsPage(QWidget *parent) :
     {
         ui->CheckboxAMDSMBusReduceCPU->setChecked(drivers_settings["amd_smbus_reduce_cpu"]);
     }
+
+    if(drivers_settings.contains("shared_smbus_access"))
+    {
+        ui->CheckboxSharedSMBusAccess->setChecked(drivers_settings["shared_smbus_access"]);
+    }
+    else
+    {
+        ui->CheckboxSharedSMBusAccess->setChecked(true);
+    }
 #else
     ui->DriversSettingsLabel->hide();
     ui->CheckboxAMDSMBusReduceCPU->hide();
+    ui->CheckboxSharedSMBusAccess->hide();
 #endif
 
     UpdateProfiles();
@@ -672,3 +682,12 @@ void Ui::OpenRGBSettingsPage::on_CheckboxAMDSMBusReduceCPU_clicked()
     SaveSettings();
 }
 
+void Ui::OpenRGBSettingsPage::on_CheckboxSharedSMBusAccess_clicked()
+{
+    json drivers_settings = ResourceManager::get()->GetSettingsManager()->GetSettings("Drivers");
+    drivers_settings["shared_smbus_access"] = ui->CheckboxSharedSMBusAccess->isChecked();
+    ResourceManager::get()->GetSettingsManager()->SetSettings("Drivers", drivers_settings);
+    SaveSettings();
+}
+
+
diff --git a/qt/OpenRGBSettingsPage.h b/qt/OpenRGBSettingsPage.h
index 02060f07..e5832719 100644
--- a/qt/OpenRGBSettingsPage.h
+++ b/qt/OpenRGBSettingsPage.h
@@ -60,6 +60,7 @@ private slots:
     void on_OpenSettingsFolderButton_clicked();
     void on_CheckboxLogConsole_clicked();
     void on_CheckboxAMDSMBusReduceCPU_clicked();
+    void on_CheckboxSharedSMBusAccess_clicked();
 
     void on_CheckboxSetOnExit_clicked(bool checked);
     void on_ComboBoxExitProfile_currentTextChanged(const QString exit_profile_name);
diff --git a/qt/OpenRGBSettingsPage.ui b/qt/OpenRGBSettingsPage.ui
index a35dbcd5..4c50898f 100644
--- a/qt/OpenRGBSettingsPage.ui
+++ b/qt/OpenRGBSettingsPage.ui
@@ -29,17 +29,24 @@
      <widget class="QWidget" name="scrollAreaWidgetContents_2">
       <property name="geometry">
        <rect>
-        <x>-67</x>
-        <y>-258</y>
-        <width>465</width>
-        <height>724</height>
+        <x>0</x>
+        <y>0</y>
+        <width>408</width>
+        <height>556</height>
        </rect>
       </property>
       <layout class="QGridLayout" name="gridLayout_3">
-       <item row="14" column="0">
-        <widget class="QCheckBox" name="CheckboxAutoStart">
+       <item row="9" column="0">
+        <widget class="QLabel" name="LogManagerSettingsLabel">
          <property name="text">
-          <string>Start At Login</string>
+          <string>Log Manager Settings:</string>
+         </property>
+        </widget>
+       </item>
+       <item row="2" column="0">
+        <widget class="QLabel" name="UserInterfaceSettingsLabel">
+         <property name="text">
+          <string>User Interface Settings:</string>
          </property>
         </widget>
        </item>
@@ -50,20 +57,33 @@
          </property>
         </widget>
        </item>
-       <item row="25" column="1">
-        <widget class="QComboBox" name="ComboBoxExitProfile"/>
+       <item row="24" column="1">
+        <widget class="QLineEdit" name="TextCustomArgs"/>
        </item>
-       <item row="10" column="0">
-        <widget class="QCheckBox" name="CheckboxLogConsole">
+       <item row="25" column="1">
+        <widget class="QComboBox" name="ComboBoxAutoStartProfile"/>
+       </item>
+       <item row="8" column="0">
+        <widget class="QCheckBox" name="CheckboxRunZoneChecks">
          <property name="text">
-          <string>Enable Log Console (restart required)</string>
+          <string>Run zone checks on rescan</string>
          </property>
         </widget>
        </item>
        <item row="26" column="0">
-        <widget class="QLabel" name="AutoStartStatusLabel">
+        <widget class="QCheckBox" name="CheckboxSetOnExit">
          <property name="text">
-          <string>Start at Login Status</string>
+          <string>Set Profile on Exit</string>
+         </property>
+        </widget>
+       </item>
+       <item row="26" column="1">
+        <widget class="QComboBox" name="ComboBoxExitProfile"/>
+       </item>
+       <item row="19" column="0">
+        <widget class="QCheckBox" name="CheckboxAutoStartMinimized">
+         <property name="text">
+          <string>Start Minimized</string>
          </property>
         </widget>
        </item>
@@ -75,54 +95,47 @@
         </widget>
        </item>
        <item row="23" column="0">
-        <widget class="QCheckBox" name="CheckboxAutoStartCustom">
+        <widget class="QCheckBox" name="CheckboxAutoStartClient">
          <property name="text">
-          <string>Custom Arguments</string>
+          <string>Start Client</string>
          </property>
         </widget>
        </item>
-       <item row="19" column="0">
+       <item row="20" column="0">
         <widget class="QCheckBox" name="CheckboxAutoStartServer">
          <property name="text">
           <string>Start Server</string>
          </property>
         </widget>
        </item>
-       <item row="3" column="0">
-        <widget class="QLabel" name="ThemeLabel">
+       <item row="21" column="1">
+        <widget class="QLineEdit" name="TextServerHost"/>
+       </item>
+       <item row="21" column="0">
+        <widget class="QCheckBox" name="CheckboxAutoStartSetServerHost">
          <property name="text">
-          <string>Theme (restart required)</string>
+          <string>Set Server Host</string>
          </property>
         </widget>
        </item>
-       <item row="9" column="0">
-        <widget class="QLabel" name="LogManagerSettingsLabel">
+       <item row="10" column="0">
+        <widget class="QCheckBox" name="CheckboxLogConsole">
          <property name="text">
-          <string>Log Manager Settings:</string>
+          <string>Enable Log Console (restart required)</string>
+         </property>
+        </widget>
+       </item>
+       <item row="14" column="0">
+        <widget class="QLabel" name="AutoStartLabel">
+         <property name="text">
+          <string>Start At Login Settings:</string>
          </property>
         </widget>
        </item>
        <item row="3" column="1">
         <widget class="QComboBox" name="ComboBoxTheme"/>
        </item>
-       <item row="18" column="0">
-        <widget class="QCheckBox" name="CheckboxAutoStartMinimized">
-         <property name="text">
-          <string>Start Minimized</string>
-         </property>
-        </widget>
-       </item>
-       <item row="2" column="0">
-        <widget class="QLabel" name="UserInterfaceSettingsLabel">
-         <property name="text">
-          <string>User Interface Settings:</string>
-         </property>
-        </widget>
-       </item>
        <item row="22" column="1">
-        <widget class="QLineEdit" name="TextClientHost"/>
-       </item>
-       <item row="21" column="1">
         <widget class="QLineEdit" name="TextServerPort">
          <property name="inputMask">
           <string>90000</string>
@@ -135,13 +148,6 @@
          </property>
         </widget>
        </item>
-       <item row="21" column="0">
-        <widget class="QCheckBox" name="CheckboxAutoStartSetServerPort">
-         <property name="text">
-          <string>Set Server Port</string>
-         </property>
-        </widget>
-       </item>
        <item row="4" column="0">
         <widget class="QCheckBox" name="CheckboxMinimizeOnClose">
          <property name="text">
@@ -149,17 +155,45 @@
          </property>
         </widget>
        </item>
-       <item row="13" column="0">
-        <widget class="QLabel" name="AutoStartLabel">
+       <item row="5" column="0">
+        <widget class="QCheckBox" name="CheckboxTrayIconGreyscale">
          <property name="text">
-          <string>Start At Login Settings:</string>
+          <string>Greyscale Tray Icon</string>
          </property>
         </widget>
        </item>
-       <item row="24" column="1">
-        <widget class="QComboBox" name="ComboBoxAutoStartProfile"/>
-       </item>
        <item row="27" column="0">
+        <widget class="QLabel" name="AutoStartStatusLabel">
+         <property name="text">
+          <string>Start at Login Status</string>
+         </property>
+        </widget>
+       </item>
+       <item row="3" column="0">
+        <widget class="QLabel" name="ThemeLabel">
+         <property name="text">
+          <string>Theme (restart required)</string>
+         </property>
+        </widget>
+       </item>
+       <item row="15" column="0">
+        <widget class="QCheckBox" name="CheckboxAutoStart">
+         <property name="text">
+          <string>Start At Login</string>
+         </property>
+        </widget>
+       </item>
+       <item row="23" column="1">
+        <widget class="QLineEdit" name="TextClientHost"/>
+       </item>
+       <item row="22" column="0">
+        <widget class="QCheckBox" name="CheckboxAutoStartSetServerPort">
+         <property name="text">
+          <string>Set Server Port</string>
+         </property>
+        </widget>
+       </item>
+       <item row="28" column="0">
         <spacer name="verticalSpacer">
          <property name="orientation">
           <enum>Qt::Vertical</enum>
@@ -175,27 +209,6 @@
          </property>
         </spacer>
        </item>
-       <item row="6" column="0">
-        <widget class="QCheckBox" name="CheckboxLoadGeometry">
-         <property name="text">
-          <string>Load Window Geometry</string>
-         </property>
-        </widget>
-       </item>
-       <item row="22" column="0">
-        <widget class="QCheckBox" name="CheckboxAutoStartClient">
-         <property name="text">
-          <string>Start Client</string>
-         </property>
-        </widget>
-       </item>
-       <item row="8" column="0">
-        <widget class="QCheckBox" name="CheckboxRunZoneChecks">
-         <property name="text">
-          <string>Run zone checks on rescan</string>
-         </property>
-        </widget>
-       </item>
        <item row="11" column="0">
         <widget class="QLabel" name="DriversSettingsLabel">
          <property name="text">
@@ -203,40 +216,34 @@
          </property>
         </widget>
        </item>
-       <item row="24" column="0">
+       <item row="25" column="0">
         <widget class="QCheckBox" name="CheckboxAutoStartProfile">
          <property name="text">
           <string>Load Profile</string>
          </property>
         </widget>
        </item>
-       <item row="23" column="1">
-        <widget class="QLineEdit" name="TextCustomArgs"/>
-       </item>
-       <item row="5" column="0">
-        <widget class="QCheckBox" name="CheckboxTrayIconGreyscale">
+       <item row="6" column="0">
+        <widget class="QCheckBox" name="CheckboxLoadGeometry">
          <property name="text">
-          <string>Greyscale Tray Icon</string>
+          <string>Load Window Geometry</string>
          </property>
         </widget>
        </item>
-       <item row="25" column="0">
-        <widget class="QCheckBox" name="CheckboxSetOnExit">
+       <item row="24" column="0">
+        <widget class="QCheckBox" name="CheckboxAutoStartCustom">
          <property name="text">
-          <string>Set Profile on Exit</string>
+          <string>Custom Arguments</string>
          </property>
         </widget>
        </item>
-       <item row="20" column="0">
-        <widget class="QCheckBox" name="CheckboxAutoStartSetServerHost">
+       <item row="13" column="0">
+        <widget class="QCheckBox" name="CheckboxSharedSMBusAccess">
          <property name="text">
-          <string>Set Server Host</string>
+          <string>Shared SMBus Access (restart required)</string>
          </property>
         </widget>
        </item>
-       <item row="20" column="1">
-        <widget class="QLineEdit" name="TextServerHost"/>
-       </item>
       </layout>
      </widget>
     </widget>